Super Eagles forward Victor Osimhen netted the opener for Christophe Galtier’s Lille the perfect start on Friday night.
The Nigerian international latched onto Jonathan Bamba’s long ball over the top in the 14th minute before lobbing home his 12th league goal of the season.
Renato Sanches wrapped up the points with 15 minutes to play, as the Portuguese Euro 2016 winner raced through on goal and drilled a low finish into the bottom corner.
Reigning champions and runaway league leaders Paris Saint-Germain, who sit 12 points ahead of Marseille, welcome Lyon to the Parc des Princes on Sunday.
Interestingly, Sanches goal saw Lille claim a 2-0 victory at Angers on Friday to move level on points with third-placed Rennes.
Rennes host Brest on Saturday when second-placed Marseille, six points clear of Lille, take on rock-bottom Toulouse.