Real Madrid will face Leganes in the last 16 of the Copa del Rey while holders Barcelona take on Levante.
The other ties are: Girona vs Atletico Madrid, Getafe vs Valladolid, Betis vs Real Sociedad, Sporting vs Valencia, Athletic vs Sevilla and Villarreal vs Espanyol.
First legs will be played between the 8th and 10th of January with the return matches the following week.
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“It is clear that Leganes do not bring back good memories for us,” said Real Madrid director Emilio Butragueno.
Meanwhile on Barcelona’s draw with Levante, club representative Guillermo Amor said: “We play against them on Sunday and it is okay.”